Research Clusters

Bringing together mouse genetics with complementary capabilities across human, cell, tissue and in silico systems


Cancer

Using complex state-of-the-art mouse models of cancer that take advantage of deep molecular and spatial phenotyping to improve the understanding and treatment of human cancer.

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  • CRUK Beatson Institute

    University of Glasgow logo

    University of Glasgow

  • Institute of Cancer Research

    Queen's University Belfast logo

    Queen’s University Belfast

  • University of Oxford logo

    University of Oxford

    CRUK Edinburgh Centre

  • University of Edinburgh logo

    University of Edinburgh

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    Congenital Anomalies

    Patient-led functional genomics – generation of precisely engineered mouse models of gene variants identified in patients and improved automated monitoring of early life.

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    • King's College London logo

      King’s College London

      UCL Great Ormond Street Institute of Child Health logo

      UCL Great Ormond Street Institute of Child Health

    • Newcastle University logo

      Newcastle University

      MRC Human Genetics Unit

    • University of Edinburgh logo

      University of Edinburgh

      MRC Weatherall Institute of Molecular Medicine logo

      MRC Weatherall Institute of Molecular Medicine

    • University of Oxford logo

      University of Oxford

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      Degron Tagging

      Precision control of protein dosage – our cluster aims to translate degron technologies into mouse models of human disease and share protocols with the community.

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      • MRC Human Genetics Unit

        University of Edinburgh logo

        University of Edinburgh

      • MRC Protein Phosphorylation and Ubiquitylation Unit

        MRC Protein Phosphorylation and Ubiquitylation Unit

        University of Dundee logo

        University of Dundee

      • CRUK Edinburgh Centre

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        Haem

        Developing new tools to revolutionise how we study normal and stressed haematopoiesis, and how we map and manipulate immune cell function for clinical benefit.

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        • University of York logo

          University of York

          Wellcome-MRC Cambridge Stem Cell Institute logo

          Wellcome-MRC Cambridge Stem Cell Institute

        • University of Cambridge logo

          University of Cambridge

          Imperial College London logo

          Imperial College London

        • Francis Crick Institute logo

          Francis Crick Institute

          MRC Laboratory of Molecular Biology logo

          MRC Laboratory of Molecular Biology

        • MRC Molecular Haematology Unit logo

          MRC Molecular Haematology Unit

          MRC Weatherall Institute of Molecular Medicine logo

          MRC Weatherall Institute of Molecular Medicine

        • University of Oxford logo

          University of Oxford

          University of Edinburgh logo

          University of Edinburgh

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          Microbiome

          Mouse models of barrier immunity dysfunction will allow investigation of the impact of the microbiome in human diseases involving barrier surfaces and new drug development.

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          • Kennedy Institute of Rheumatology logo

            Kennedy Institute of Rheumatology

            University of Oxford logo

            University of Oxford

          • MRC Centre for Medical Mycology logo

            MRC Centre for Medical Mycology

            University of Exeter logo

            University of Exeter

          • Imperial College London logo

            Imperial College London

            EMBL-EBI

          • University of Manchester logo

            University of Manchester

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            Mitochondria

            An integrated phenotyping and mouse model generation platform for mitochondrial disease and dysfunction that aims to deliver new insights, therapies, and biomarkers.

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            • UCL Queen Square Institute of Neurology logo

              UCL Queen Square Institute of Neurology

              MRC Mitochondrial Biology Unit logo

              MRC Mitochondrial Biology Unit

            • University of Cambridge logo

              University of Cambridge

              Wellcome Centre for Mitochondrial Research logo

              Wellcome Centre for Mitochondrial Research

            • Newcastle University logo

              Newcastle University

              EMBL-EBI

            • University of Padua Department of Biomedical Sciences logo

              University of Padua Department of Biomedical Sciences

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              MURIDAE

              MURIDAE (Modalities for Understanding, Recording and Integrating Data Across Early life) aims to improve the translatability of mouse models for neuropsychiatric and neurodevelopmental disease.

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              • MRC Centre for Neuropsychiatric Genetics and Genomics logo

                MRC Centre for Neuropsychiatric Genetics and Genomics

                Cardiff University logo

                Cardiff University

              • University of Bristol logo

                University of Bristol

                University of Leeds logo

                University of Leeds

              • Lancaster University

                MRC Centre for Neurodevelopmental Disorders

              • King's College London logo

                King’s College London

                University of Oxford logo

                University of Oxford

              • Nucleic Acid Therapy Accelerator logo

                Nucleic Acid Therapy Accelerator

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