Using complex state-of-the-art mouse models of cancer that take advantage of deep molecular and spatial phenotyping to improve the understanding and treatment of human cancer.
Patient-led functional genomics – generation of precisely engineered mouse models of gene variants identified in patients and improved automated monitoring of early life.
Precision control of protein dosage – our cluster aims to translate degron technologies into mouse models of human disease and share protocols with the community.
Developing new tools to revolutionise how we study normal and stressed haematopoiesis, and how we map and manipulate immune cell function for clinical benefit.
University of York
Wellcome-MRC Cambridge Stem Cell Institute
University of Cambridge
Imperial College London
Francis Crick Institute
MRC Laboratory of Molecular Biology
MRC Molecular Haematology Unit
MRC Weatherall Institute of Molecular Medicine
University of Oxford
University of Edinburgh
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Mouse models of barrier immunity dysfunction will allow investigation of the impact of the microbiome in human diseases involving barrier surfaces and new drug development.
An integrated phenotyping and mouse model generation platform for mitochondrial disease and dysfunction that aims to deliver new insights, therapies, and biomarkers.
MURIDAE (Modalities for Understanding, Recording and Integrating Data Across Early life) aims to improve the translatability of mouse models for neuropsychiatric and neurodevelopmental disease.