Research Clusters

Bringing together mouse genetics with complementary capabilities across human, cell, tissue and in silico systems


Ageing

Building a time-resolved high-resolution map of age associated phenotypic, cellular and molecular changes in the mouse

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  • Newcastle University logo

    Newcastle University

    University of Cambridge logo

    University of Cambridge

  • Wellcome-MRC Cambridge Stem Cell Institute logo

    Wellcome-MRC Cambridge Stem Cell Institute

    Babraham Institute

  • Cancer Research UK Cambridge Institute

    UK Dementia Research Institute

  • UCL Queen Square Institute of Neurology logo

    UCL Queen Square Institute of Neurology

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    Cancer

    Using complex state-of-the-art mouse models of cancer that take advantage of deep molecular and spatial phenotyping to improve the understanding and treatment of human cancer.

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    • Cancer Research UK Scotland Institute

      University of Glasgow logo

      University of Glasgow

    • Institute of Cancer Research

      Queen's University Belfast logo

      Queen’s University Belfast

    • University of Oxford logo

      University of Oxford

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      Congenital Anomalies

      Patient-led functional genomics – generation of precisely engineered mouse models of gene variants identified in patients and improved automated monitoring of early life.

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      • King's College London logo

        King’s College London

        UCL Great Ormond Street Institute of Child Health logo

        UCL Great Ormond Street Institute of Child Health

      • Newcastle University logo

        Newcastle University

        MRC Human Genetics Unit

      • University of Edinburgh logo

        University of Edinburgh

        MRC Weatherall Institute of Molecular Medicine logo

        MRC Weatherall Institute of Molecular Medicine

      • University of Oxford logo

        University of Oxford

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        Degron Tagging

        Precision control of protein dosage – our cluster aims to translate degron technologies into mouse models of human disease and share protocols with the community.

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        • MRC Human Genetics Unit

          University of Edinburgh logo

          University of Edinburgh

        • MRC Protein Phosphorylation and Ubiquitylation Unit

          MRC Protein Phosphorylation and Ubiquitylation Unit

          University of Dundee logo

          University of Dundee

        • CRUK Edinburgh Centre

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          Haem

          Developing new tools to revolutionise how we study normal and stressed haematopoiesis, and how we map and manipulate immune cell function for clinical benefit.

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          • University of York logo

            University of York

            Wellcome-MRC Cambridge Stem Cell Institute logo

            Wellcome-MRC Cambridge Stem Cell Institute

          • University of Cambridge logo

            University of Cambridge

            Imperial College London logo

            Imperial College London

          • Francis Crick Institute logo

            Francis Crick Institute

            MRC Laboratory of Molecular Biology logo

            MRC Laboratory of Molecular Biology

          • MRC Molecular Haematology Unit logo

            MRC Molecular Haematology Unit

            MRC Weatherall Institute of Molecular Medicine logo

            MRC Weatherall Institute of Molecular Medicine

          • University of Oxford logo

            University of Oxford

            University of Edinburgh logo

            University of Edinburgh

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            Microbiome

            Mouse models of barrier immunity dysfunction will allow investigation of the impact of the microbiome in human diseases involving barrier surfaces and new drug development.

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            • Kennedy Institute of Rheumatology logo

              Kennedy Institute of Rheumatology

              University of Oxford logo

              University of Oxford

            • MRC Centre for Medical Mycology logo

              MRC Centre for Medical Mycology

              University of Exeter logo

              University of Exeter

            • Imperial College London logo

              Imperial College London

              EMBL-EBI

            • University of Manchester logo

              University of Manchester

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              Mitochondria

              An integrated phenotyping and mouse model generation platform for mitochondrial disease and dysfunction that aims to deliver new insights, therapies, and biomarkers.

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              • UCL Queen Square Institute of Neurology logo

                UCL Queen Square Institute of Neurology

                MRC Mitochondrial Biology Unit logo

                MRC Mitochondrial Biology Unit

              • University of Cambridge logo

                University of Cambridge

                Wellcome Centre for Mitochondrial Research logo

                Wellcome Centre for Mitochondrial Research

              • Newcastle University logo

                Newcastle University

                EMBL-EBI

              • University of Padua Department of Biomedical Sciences logo

                University of Padua Department of Biomedical Sciences

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                MURIDAE

                MURIDAE (Modalities for Understanding, Recording and Integrating Data Across Early life) aims to improve the translatability of mouse models for neuropsychiatric and neurodevelopmental disease.

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                • Cardiff University logo

                  Cardiff University

                  University of Bristol logo

                  University of Bristol

                • University of Leeds logo

                  University of Leeds

                  Lancaster University

                • MRC Centre for Neurodevelopmental Disorders

                  King's College London logo

                  King’s College London

                • University of Oxford logo

                  University of Oxford

                  Nucleic Acid Therapy Accelerator logo

                  Nucleic Acid Therapy Accelerator

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