The MRC National Mouse Genetics Network

A package of distinctive research clusters drawing from the specialist facilities and capabilities of the Mary Lyon Centre at MRC Harwell to accelerate our understanding of human disease.

How to get involved More about the Network

Illustration of the community and collaboration of the Nation Mouse Genetics Network
Latest News

Rare Disease Community Event – meeting report

On the 6th of June 2024 the MRC National Mouse Genetics Network (NMGN) and the Mary Lyon Centre at MRC…

Capitalising on the UK’s excellence in genetics, the Network drives:

Illustration of the Mary Lyon Centre as the centre of the Nation Mouse Genetics Network

Research integration

Basic science research in genetics, cell and tissue systems, and deep phenotyping will be integrated with clinical findings and requirements

Illustration of the clusters that are a part of the Nation Mouse Genetics Network

National partnerships

Coordination within and between areas of interest in challenge-led clusters will help address priority disease areas

Illustration of the National Mouse Gentics Network promoting 3Rs

Promotion of the 3Rs

Methods for the optimised production, archiving, and sharing of genetically altered mice will be shared to ensure welfare and high quality science

Illustration of the resource sharing within the Nation Mouse Genetics Network

Resource sharing

Resources, data, and access to world-class practical and theoretical training courses will be shared through the Mary Lyon Centre at MRC Harwell

Challenge-Led Research Clusters

Distributed clusters provide a platform to support ambitious, multi-dimensional and thematically-focused research that brings together mouse genetics with complementary capabilities across human, cell, tissue, and in silico systems. Our 8 Clusters are: Ageing, Cancer, Congenital Diseases, Degron Tagging, Haem, Microbiome, Mitochondria, and MURIDAE.

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Congenital Anomalies Cluster

Patient-led functional genomics – generation of precisely engineered mouse models of gene variants identified in patients and improved automated monitoring of early life.

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Degron Tagging Cluster

Precision control of protein dosage – our cluster aims to translate degron technologies into mouse models of human disease and share protocols with the community.

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Microbiome Cluster

Mouse models of barrier immunity dysfunction will allow investigation of the impact of the microbiome in human diseases involving barrier surfaces and new drug development.

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Member Organisation

Working Groups

The Network has a set of Working Groups focusing on issues that are important across the whole Network.

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Best Models

Horizon Scanning

Industry and Translation

Public Partnership

Training

How your research can benefit from the Network

Funding opportunities, scientific collaboration and resource sharing are all available through the Network

Connectivity

Connect with other researchers working on your disease of interest or in related areas and form collaborations that accelerate and benefit your investigations

Training

World-class practical and theoretical training courses in genetics, genome editing, and all areas of laboratory animal science to support the development of your team

Resources

Gain access to a range of resources, including mice and data, that are available to all Associates of the Network

Discussions

Discussions and information on the best use of in vivo resources and opportunities for replacement, reduction, and refinement (3Rs)

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Any questions? Get in touch with The Network

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