Basic science research in genetics, cell and tissue systems, and deep phenotyping will be integrated with clinical findings and requirements
Coordination within and between areas of interest in challenge-led clusters will help address priority disease areas
Promotion of the 3Rs
Methods for the optimised production, archiving, and sharing of genetically altered mice will be shared to ensure welfare and high quality science
Resources, data, and access to world-class practical and theoretical training courses will be shared through the Mary Lyon Centre at MRC Harwell
Challenge-Led Research Clusters
Distributed clusters provide a platform to support ambitious, multi-dimensional and thematically-focused research that brings together mouse genetics with complementary capabilities across human, cell, tissue, and in silico systems. Our 7 clusters are: Congenital Diseases, Mitochondria, Haematology, Cancer, Microbiome, MURIDAE, and Degron Tagging.
Congenital Anomalies Cluster
Patient-led functional genomics – generation of precisely engineered mouse models of gene variants identified in patients and improved automated monitoring of early life.
Degron Tagging Cluster
Precision control of protein dosage – our cluster aims to translate degron technologies into mouse models of human disease and share protocols with the community.
Mouse models of barrier immunity dysfunction will allow investigation of the impact of the microbiome in human diseases involving barrier surfaces and new drug development.