Find the right expertise for your project
We connect researchers with specialists in diverse model systems to support innovation and refinement.
Our experts cover a broad range of biological models, from cell-based systems and organoids to invertebrates, fish, and mammalian models.
If you are considering alternatives or want advice on selecting the most appropriate model, or method, for your research, contact the NMGN Best Models Working Group.
 | Dr Cathy Vickers – 3Rs Head of Innovation, NC3Rs Broad perspective on the 3Rs and Replacement |
 | Dr Lydia Teboul – Mouse models Head of Molecular and Cellular Biology, Mary Lyon Center at MRC Harwell Developing methods of generation and validation of engineered alleles |
 | Dr Douglas Strathdee – Mouse models Head of Transgenic Technology Facility, CRUK Scotland Institute Generation of mouse models of human disease |
 | Dr William Grey – PDX and ex vivo models Group Leader PROTEOSTEM, University of York My group studies the role of protein homeostasis in human samples and mouse models of healthy and malignant blood stem cells. Haematology – PDX and ex vivo model systems for studying healthy and malignant stem cells. |
 | Prof Karen Blyth – Mouse models / in vitro Group Leader In Vivo Cancer Biology, CRUK Scotland Institute Using genetic and transplantation mouse models of cancer to better understand the mechanisms of cancer biology and discover new and repurposed therapeutic options for treating the disease. Obviously, we use in vitro models (cell culture and 3D models) prior to any mouse work and then in parallel to discern molecular pathways and mechanisms. |
 | Dr Xiao Fu – Integrative modelling Senior Lecturer Integrative Modelling, CRUK Scotland Institute Integrative data science and computational modelling approaches to study cancer. |
 | Dr Alex Benedetto – C. elegans Senior lecturer in Integrative Physiology, Lancaster University Integrative physiology, gut-brain axis, stress, ageing, death, brain imaging, microscopy. |
  | Prof Matthew Guille – Xenopus Professor of Developmental Genetics, University of Portsmouth Dr Annie Godwin – Xenopus Senior Lecturer Protein Engineering and Synthetic Biology, University of Portsmouth We make, quality assure and curate genetically altered Xenopus models for the community together with holding and distributing >1.5M DNA constructs for working with frogs. The main research we do is to work closely with geneticists to re-create in tadpoles, novel human gene variants thought to cause disease. This is to test the link between the gene variant and disease helping to provide diagnoses for the >50% of rare disease patients who do not have one. |
 | Prof Karen Liu – Mouse models / Human Stem Cells / Xenopus Professor of Genetics and Development, King’s College London I work on congenital anomalies arising during embryonic development. This includes common anomalies such as cleft palate, craniosynostosis and congenital heart disease as well as rare genetic anomalies. We aim to understand the causes of these disorders to improve diagnostics and to identify new avenues for therapeutics. |
 | Prof Julia Cordero – Drosophila Group Leader Local and Systemic Functions of the Intestine in Health and Disease, CRUK Scotland Institute Intestinal biology research. Stem cells. Tissue regeneration. Colorectal cancer. Interorgan signalling |
